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Clinical data
Trade namesNolvadex, Genox, Tamifen, others [1]
Pregnancy categoryAU: B3 US: D (Evidence of risk)
Routes of administrationBy mouth
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Protein binding99%
MetabolismHepatic (CYP3A4, 2C9 and 2D6)
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3% for placebo. In other adjuvant studiesthe Toronto nolvadex cycle pct and Tamoxifen Adjuvant Trial Organization NATO women received either tamoxifen or no therapy see Clinical Studies 14.it was a nolvadex cycle pct agonist, with high affinity but low intrinsic activity 5.

This was a pharmacological action with which ICI researchers had become familiar in their work on the beta-blockers Quirke, 2006 It helped to cast further light on the physiological processes at a molecular level36, and made tamoxifen a particularly useful research tool for investigations of hormone-dependent tumors Jordan et al.

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